The potential involvement of JAK-STAT signaling pathway in the COVID-19 infection assisted by ACE2

•COVID-19 keeps substantial nucleotide similarity and shares common receptor (ACE2) with SARS-Cov.•ACE2 was overexpressed in both SARS-Cov and SARS-Cov-2 infection and might regulate immunological pathways in COVID-19.•SARS-Cov-2 infection was accompanied by the activation and inhibition of immunological cells.•JAK-STAT signaling pathway participated in COVID-19 infection subsequent the overactivation of ACE2.