Synthesis of a series of aldol compounds by direct LDA reaction from pyruvaldehyde dimethyl acetal and 3-arylmethylidine pentane-2,4-diones by Knoevenagel reaction

A new convenient synthesis of aldol compounds starting from pyruvaldehyde dimethyl acetal has been described. This method conveniently led to the synthesis of some biologically important compounds(1,2). A new synthesis of 3-arylmethylidine pentane-2,4-diones is reported via usual Knoevenagel condensation which has a significant role in synthesizing different sensors for metal cations or anions.