Phosphotungstic Acid Catalyzed One-Pot Synthesis of 2-amino-3,5-dicarbonitrile-6-thio-pyridines in Aqueous Media

In this study, we report the one-pot synthesis of 2-amino-3,5-dicarbonitrile-6-thiopyridines with benzaldehyde, malononitrile, and thiophenol by using phosphotungstic acid as an efficient catalyst in aqueous media. This method has the advantages of easy separation, high storage stability, and environmental friendliness.