Effect of recombinant crustacean hyperglycemic hormones rCHH-B1 and rCHH-B2 on lipid metabolism in the Pacific white shrimpLitopenaeus vannamei
AQUACULTURE RESEARCH(2020)
摘要
The crustacean hyperglycemic hormones (CHH) are pleiotropic neuropeptides controlling diverse processes in the life cycle of crustaceans. In the Pacific white shrimpLitopenaeus vannamei, CHH-B1 and CHH-B2 are generated by alternative splicing of the same gene, and the recombinant versions of these peptides have shown differential effects on glucose metabolism and osmoregulation in this species. In this work, we explored the role of both recombinant variants, expressed in yeastPichia pastoris, on lipid metabolism. The results showed that rCHH-B1 and rCHH-B2 injections into eyestalk-ablated shrimp significantly increased the phospholipid and triglyceride levels in haemolymph and restored free fatty acid levels, suggesting that these CHH variants mobilize lipid reserves in shrimp. The effects on lipids were concomitant to its hyperglycemic activity, suggesting that both variants, in addition to their hyperglycemic activity, have hyperlipidemic functions.
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关键词
crustacean hyperglycemic hormone,glucose metabolism,lipid metabolism,Litopenaeus vannamei
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