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A novel ferulic acid derivative FAD012 improves cerebral blood flow and enhances swallowing reflux in a rat chronic cerebral hypoperfusion model

Takashi Asano,Hirokazu Matsuzaki,Meiyan Xuan,Kosuke Hayashi,Takeshi Sakamoto,Yasuhide Hibino,Mari Okazaki

JOURNAL OF PHARMACOLOGICAL SCIENCES（2016）

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Abstract
Dysphagia is the major complication of stroke and often leads to lethal aspiration pneumonia in the patients. In the present study, we investigated the effects of FAD012, a synthetic derivate of ferulic acid (FA), against the swallowing dysfunction induced by bilateral common carotid artery occlusion (2VO) in rats.
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Key words
reflux,cerebral blood flow,ferulic acid derivative,blood flow
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