Three-step two-pot automated production of NCA [¹⁸F]FDOPA with FlexLab module

Automated three-step two-pot production of no-carrier-added (NCA) [F-18]FDOPA was first implemented in the iPHASE FlexLab module. Decay-corrected radiochemical yield (RCY) of [F-18]FDOPA synthesized by this method was 10 similar to 14% (n = 7) with a synthesis time of similar to 110 min [F-18]FDOPA was obtained in > 95% of radiochemical purity with a molar activity of similar to 431 GBq/mu mol. With the method successfully implementing on the commercial FlexLab module and its built-in step-by-step activity monitoring, further processes optimization would be achieved.