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Juvenile polyposis lesions show clonal loss of SMAD4 in epithelial as well as stromal compartments, endorsing the "gatekeeper" not the "landscaper" hypothesis.

K Woodford-Richens,J Williamson,S Bevan,J Young,J Jass,B Leggett,I Frayling, Y Thway,S Hodgson,JC Kim,T Iwama,M Novelli,D Sheer, R Poulson, NA Wright,R Houlston,I Tomlinson

JOURNAL OF PATHOLOGY（2000）

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