Synthesis and Characterization of alpha-ZrP@CHI Drug Deliver System

This paper described the controlled synthesis and release properties of a new kind of multifunctional drug-release system which was prepared by encapsulation of zirconium bis-(monohydrogen orthophosphate) monohydrate (alpha-ZrP) with chitosan (CHI). As obtained the alpha-ZrP@CHI nanocomposites were found to possess the structural features of both alpha-ZrP and CHI. The release properties of the alpha-ZrP@CHI nanocomposites were evaluated using Gentamicin sulfate as the model drug. And alpha-ZrP@CHI composites showed a prolonged drug release time compared with alpha-ZrP, which can be attributed to the unique lamellar structure and the encapsulation with CHI. The controlled synthesis of alpha-ZrP@CHI nanocomposite thus provided a new opportunity for future development of delivery vehicles.