Solid-Liquid Equilibrium of Lamotrigine in 12 Pure Solvents from T=283.15 to 323.15 K: Experimental Determination and Thermodynamic Modeling

The solubility of lamotrigine in 12 pure solvents, including 1-propanol, isopropanol, 1-butanol, isobutanol, acetone, ethyl propionate, methyl acetate, ethanol, methyl isobutyl ketone, n-pentanol, water, and 2-butanol, was measured by using the static method in a temperature range from 283.15 to 323.15 K under atmospheric pressure (101.1 kPa). The experimental solubility data were correlated by the modified Apelblat equation, lambda h equation, nonrandom two-liquid (NRTL) models, and Wilson models. The model parameters and data error were calculated. The maximum values of root-mean-square deviation were 4.299 x 10(-4). As a result, the Apelblat model provided the best fitting. The solubility data provide the basic data for the design and optimization of lamotrigine crystallization.