THE ASSAY OF FELODIPINE BY SECOND DERIVATIVE SPECTROPHOTOMETRY

The present paper aimed the development of a new felodipine assay method, a calcium channel antagonists, used as an antihypertensive drug. The second derivative of the felodipine absorption spectra was used at wavelengths between 239 - 230 nm, in methanolic solution. It was established the concentration range for Beer's law. It was assessed that there is a linear relationship between the second derivative and the concentration of the felodipine solutions, in the range between 1.946.10(-6) and 19.46.10(-6) g/mL. The correlation coefficient and the regression equation were found to be r = 0.99975 and y = 0.00883x + 0.00487. This method proved to be sensitive, reproducible and accurate.