Preparation and Drug Release of Anti-cancer Fe3O4@ZIF-8@PA System Loaded with Drug

An anti-cancer and loading drug system was prepared. Fe3O4 nanopartiles prepared by hydrothermal method was chosen as substrate to design and fabricate pH responsive magnetic nanocomposites Fe3O4@ZIF-8@PA with core-shell structure. This nanomaterial exhibited high saturation of 35.46 A . m(2)/g and maintained well magnetic property. Fe3O4 nanopartiles showed spherical structure and good dispersion. Compared with the substrate, the particle size of composite microsphere increased significantly, but still con. form to the ideal carrier material size. In addition, the carriers with porous structures showed large surface are-a, high drug loading efficiency and capacity for doxorubicin(DOX) of up to 96.4% and 144.6 mg/g. The drug release of nanopartiles loaded with drug was studied in pH = 7. 4 and 5.0. The total released percentage of two kinds of pH were 39.8% and 78.6%, respectively. The drug releasing experiment was also to perform to verify the constructed nanocarriers excellent pH. response. The introduction of phytic acid with inhibition to cancer cells made it possible that the carriers could kill tumor cells. The methyl thiazolyl tetrazolium(MTT) test act on human osteosarcoma cell line(MG-63) was also carried out in vitro to demonstrate the combination effect of anticancer between the carriers and DOX.