Construction of Controllable Lipid-DNA Complex for Study in Membrane Biology

This review briefly summarized recent progress of lipid-DNA complexes, including their design, construction , and unique features. We highlighted their applications on living cell membranes , including dynamic membrane analysis, nanopores , live cell organization and interaction regulation, and drug delivery. We also summarized challenges in this field. We suggest that by using these lipid-DNA conjugates, cell membrane functions at the molecular level can be better understood and manipulated , which may facilitate the development of cell imaging, theranostics , construction of nanodevices and protocells.