Recurrent Autoimmune Hepatitis And De Novo Autoimmune Hepatitis In The Liver Allograft

Objectives: Autoimmune hepatitis (AIH) is a form of severe hepatitis that can recur after orthotopic liver transplant (OLT). Presentation of AIH in patients with OLT who do not have a history of AIH is called de novo AIH ( DNAIH). We evaluated the clinicopathologic characteristics of AIH and DNAIH.Methods: Clinicopathologic and outcome measures of 11 patients with recurrent AIH (RAIH) and 22 with DNAIH identified between 2000 and 2017 were compared.Results: Both cohorts showed female predominance. The mean clinical follow-up was 13 and 7.8 years in the in the RAIH and DNAIH groups, respectively (P = .1). Moderate portal inflammation was more common in patients with RAIH (64% vs 27%, P = .043 ). A trend was observed for more cases of DNAIH showing severe inflammation ( 36% vs 9%, P = .09) and submassive necrosis compared with RAIH ( 23% vs 0%, P = .086). A trend for more advanced fibrosis was also noted in the RAIN group ( 27% vs 5%, P = .059). Three patients with RAIN lost their grafts because of RAIH. Five-year disease-specific graft survival (GS) (P = .012) and overall GS (P = .015) were worse in patients with RANT Complement component 4d immunohistochemistry was positive in 2 patients with RAIH and 3 with DNAIH but showed no correlation with GS or other parameters.Conclusions: RAIH seems to have a more aggressive clinical course than DNAIH and warrants closer clinical follow-up and aggressive treatment.