Faim-S Functions As A Negative Regulator Of Nf-Kappa B Pathway And Blocks Cell Cycle Progression In Nsclc Cells
CELL CYCLE(2020)
摘要
Tumorigenesis is closely related to the disorder of the cell cycle. The cell cycle progression includes the interphase (G0/G1, S, and G2 phase) and mitosis (M phase). CCND1 is a key protein that regulates the entry of the G0/G1 phase into the S phase. In our study, we found that the short form of Fas Apoptosis Inhibitory Molecule 1 (FAIM-S) could regulate the expression of CCND1 and had a tumor-suppressing role in non-small cell lung cancer (NSCLC). Overexpressing FAIM-S significantly inhibited the proliferation and cell cycle progression in NSCLC cells. Further studies demonstrated that FAIM-S could interact with IKK-alpha, reducing its protein stability. This effect led to the suppression of the NF-kappa B pathway, resulting in the decreased expression of CCND1. Thus, our study demonstrated that FAIM-S functioned as a negative regulator of the NF-kappa B pathway and played a tumor-suppressing role through blocking cell cycle progression in NSCLC cells.
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关键词
FAIM-S, CCND1, cell cycle, NF-κ, B, non-small cell lung cancer
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