A review of antimicrobial photodynamic therapy (aPDT) in periodontitis

Introduction:Periodontitis is an inflammatory disease caused by a multitude of pathogens, that eventually affects the entirety of all periodontal tissues and may lead to tooth mobility or even tooth loss. The destruction of said tissues occurs via 2 pathways: a direct pathway (defense mechanisms belonging to the pathogens) and an indirect pathway (the host's immune system). Therapy is complex and requires strict follow-ups in order to prevent relapse. Aim: Our objective was to determine whether or not aPDT can be considered to be an effective adjunctive approach to the current standard initial treatment method when dealing with periodontitis (scaling/root planing). Methods: We performed an electronical search of the PubMed and ScienceDirect data bases starting from January 2014 and up to May 2019. Eligibility criteria included English-language systematic reviews and randomized clinical trials which evaluated the efficiency of aPDT, and that had been carried out on human subjects with permanent dentition. We excluded studies and reviews that were focused on the microbiology and/or immunology in photodynamic therapy and also those that used other LASER treatment modalities than aPDT. Results: Current literature displays many opinions regarding periodontal therapy with adjunctive aPDT, but it seems to be mainly regarded as a safe, effective and easyto-use approach. Conclusion: aPDT seems to be efficient in the treatment of periodontitis when carried out additionally to classical scaling/root planing. Residual pockets seem to respond well to aPDT, as opposed to subsequent debridement flap elevation and its consequences on hard and soft tissues. However, further studies with a stricter treatment protocol and subsequent follow-ups are required in order to obtain a firmer conclusion.