Characterizing Ischaemic Tolerance in Rat Pheochromocytoma (PC12) Cells and Primary Rat Neurons

•Preconditioning with oxygen and glucose deprivation (OGD) induced ischaemic tolerance in PC12 cells and primary rat neurons.•Preconditioning with glucose deprivation (GD) was protective in PC12 cells but not primary rat neurons.•Glucose concentration in preconditioning is inversely related to the level of protection conferred in PC12 cells.•HIF1 stabilization and it’s downstream gene upregulation are associated with OGD- (but not GD-) induced ischaemic tolerance.