Study on the additive protective effect of PGLYRP3 and Bifidobacterium adolescentis Reuter 1963 on severity of DSS-induced colitis in Pglyrp3 knockout (Pglyrp3 −/−) and wild-type (WT) mice

Darab Ghadimi,Michael de Vrese,Michael Ebsen,Christoph Röcken,Sven Olaf Frahm,Janine Zahlten,Regina Fölster-Holst,Knut J Heller,Wilhelm Bockelmann

Immunobiology（2021）

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摘要

•PGLYRP3 and bifidobacteria alleviate DSS-induced colitis in Pglyrp3 knockout and wildtype mice.•Bifidobacteria appear to mitigate intestinal immunopathology in the context of Pglyrp3 blockade.

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ALT,ALB,APCs,AST,B.a,CFU,COX-2,DMC,DSS,EU/mL,GI,H & E,IACUC,IBD,IL-6,IBS,MAMPs,MoDCs,NF-kB,NIH,PBS,Pglyrp3,Pglyrp3 −/−,PIE,PRRs,PTGS2,qRT-PCR,SIgA,wk,WT

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