In Vitro Hollow-Fiber Studies Assessing Antibacterial Activity Of Ceftolozane/Tazobactam Against Multidrug-Resistant Pseudomonas Aeruginosa

Donna Carr,Zufei Zhang,Qian Si,Fred Racine,Jing Chen Xiao,Ravi Katwaru,Michael K Wismer,Matthew G Johnson,Hwa-Ping Feng,Katherine Young,Matthew L Rizk,Mary Motyl

OPEN FORUM INFECTIOUS DISEASES（2020）

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摘要

Our hollow-fiber infection model simulated the projected steady-state pharmacokinetics of ceftolozane and tazobactam in lung epithelial lining fluid of patients with pneumonia receiving 3 g of ceftolozane/tazobactam every 8 hours. Results confirmed the previously established in vitro activity of ceftolozane/tazobactam at and above approved breakpoints against multidrug-resistant Pseudomonas aeruginosa, regardless of Pseudomonas-derived cephalosporinase allele.

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关键词

antibacterial resistance, hollow-fiber infection model, pharmacokinetics/pharmacodynamics, Pseudomonas aeruginosa

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