Synthetic peptides against Trichophyton mentagrophytes and T. rubrum: Mechanisms of action and efficiency compared to griseofulvin and itraconazole

Patrícia G Lima,Pedro F N Souza,Cleverson D T Freitas,Leandro P Bezerra,Nilton A S Neto,Ayrles F B Silva, Jose T A Oliveira,Daniele O B Sousa

Life Sciences（2021）

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摘要

•All synthetic peptides tested reduced the mycelial growth of Trichophyton mentagrophytes and T. rubrum.•The synthetic peptides induced severe morphological damage in dermatophytes hyphae.•The synthetic peptides induced membrane pore formation and ROS overproduction in fungal hyphae•The synthetic peptides were more effective than the commercial drugs Griseofulvin and Itraconazole

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关键词

Synthetic antifungal peptides,Dermatophytes,Synthetic peptides,Griseofulvin,Itraconazole

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