Metal-Free Tandem Approach For Triazole-Fused Diazepinone Scaffolds Via [3+2]Cycloaddition/C-N Coupling Reaction
JOURNAL OF ORGANIC CHEMISTRY(2021)
摘要
A novel metal-free, efficient cascade reaction has been developed to construct 1,2,3-triazole-fused 1,4-diazepinone skeletons. Mechanism investigation indicated that sodium azide has not only served as a 1,3-dipoles synthon in [3 + 2] cycloaddition but also prompted C-N bond formation. Furthermore, the potential utility of this protocol was demonstrated by scale-up synthesis of 1,2,3-triazole-fused diazepinone derivatives and the derivatization of them.
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关键词
Triazole Synthesis,Diazo Compounds,Copper-Catalyzed Cycloaddition,Transition-Metal Chemistry,Transition Metal Catalysis
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