Tissue-specific genotoxicity and antioxidant imbalance of titanium dioxide nanoparticles (NPTiO2) and inorganic lead (PbII) in a neotropical fish species

Oya-Silva Laís Fernanda,Vicari Taynah,Geonildo Rodrigo Disner,Juliana Roratto Lirola,Tatiane Klingelfus, Helyandra de Lourdes Schicora Gonçalves, Thalita Pires Borges Leite,Sabrina Loise de Morais Calado,Carmen Lúcia Voigt,Helena Cristina Silva de Assis,Marta Margarete Cestari

Environmental Toxicology and Pharmacology（2021）

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摘要

•NPTiO2 caused ROS imbalances in liver tissue of Rhamdia quelen.•DNA damage in blood and kidney of R. quelen after NPTiO2+Pb exposure.•NPTiO2 + Pb were able to interact and caused alterations in biochemical biomarkers.

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关键词

Nanomaterials,Metal,Co-exposure,Comet assay,Piscine micronucleus test,Biochemical biomarkers

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