TNFAIP8 drives metabolic reprogramming to promote prostate cancer cell proliferation

Suryakant Niture,Minghui Lin, Joab O. Odera,John Moore,Hong Zhe,Xiaoxin Chen,Simeng Suy,Sean P. Collins,Deepak Kumar

The International Journal of Biochemistry & Cell Biology（2021）

引用 6|浏览22

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摘要

•TNFAIP8 activates PI3K-AKT signaling and promotes prostate cancer progression.•TNFAIP8 regulates glucose consumption and ATP production.•TNFAIP8 increases glycolysis/oxidative phosphorylation.•TNFAIP8 facilitates glycolytic metabolic reprogramming in prostate cancer cells.

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关键词

Tumor necrosis factor-α-induced protein 8 (TNFAIP8),Cell survival,PI3K-AKT pathway,Metabolic reprogramming,Glycolysis,OXPHOS,Prostate cancer

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