White matter hyperintensities classified according to intensity and spatial location reveal specific associations with cognitive performance

Luca Melazzini,Clare E. Mackay,Valentina Bordin,Sana Suri,Enikő Zsoldos,Nicola Filippini,Abda Mahmood,Vaanathi Sundaresan,Marina Codari,Eugene Duff,Archana Singh-Manoux,Mika Kivimäki,Klaus P. Ebmeier,Mark Jenkinson,Francesco Sardanelli,Ludovica Griffanti

NeuroImage: Clinical（2021）

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摘要

•Heterogeneous measures of WMHs are used in research and clinical practice.•Location and image intensity should be considered in the assessment of WMHs.•T1-hypointense WMHs were found to be associated with poorer cognitive performance.•Sub-classes of WMHs provide promising results for translation into the clinic.

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关键词

Aging,Cerebral small vessel diseases,Cognition,Magnetic resonance imaging,White matter

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