Extracellular vesicles derived from Trichinella spiralis prevent colitis by inhibiting M1 macrophage polarization

Xin Gao,Yong Yang,Xiaolei Liu,Yang Wang,Yaming Yang,Pascal Boireau,Mingyuan Liu,Xue Bai

Acta Tropica（2021）

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摘要

•Trichinella spiralis extracellular vesicles (Ts-EVs) intervened with the inflammatory responses of DSS-induced colitis in mice;•Ts-EVs inhibited M1 macrophage polarization in DSS-induced colitis;•Ts-EVs targeted both the MAPK and NF-κB pathways to regulate host immunity in DSS-induced colitis.

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关键词

Extracellular vesicles,Trichinella spiralis,DSS-induced colitis,Immunomodulation,Macrophage

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