Two New Quinazoline Derivatives from the Moss Endophytic Fungus Aspergillus sp. and Their Anti-inflammatory Activity
NATURAL PRODUCTS AND BIOPROSPECTING(2020)
Abstract
Two new quinazoline derivatives versicomides E ( 1 ) and F ( 2 ), and 10 known compounds ( 3 – 12 ) were isolated from the moss endophytic fungus Aspergillus sp. Their structures were determined on the basis of extensive spectroscopic data analysis and ECD calculations. Among them, the compound 7 (6-hydroxy-3-methoxyviridicatin) was first reported as a natural product. Inhibition on LPS-induced NO production in RAW 264.7 murine macrophages found that compounds 5 , 7 and 8 showed significant inhibitory effects on NO production, with IC 50 values of 49.85, 22.14 and 46.02 μM respectively. Graphic Abstract
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Key words
Endophytic fungus,Quinazoline,Anti-inflammatory activity
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