Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas.

Oncotarget（2020）

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摘要

The combination of TRC 102 with temozolomide is active, with 4 of 51 patients experiencing a partial response and 13 of 51 experiencing stable disease, and the side effect profile is manageable.

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关键词

DNA damage repair,MGMT,base excision repair,molecular pharmacodynamics,rational combination therapy

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