Synthesis Of 2,2 '-Dihalobiaryls Via Cu-Catalyzed Halogenation Of Cyclic Diaryliodonium Salts
ORGANIC LETTERS(2020)
Abstract
We report an efficient method for the preparation of various 2,2'-dihalobiaryls from cyclic diaryliodonium salts. With cheap halogen sources as starting materials, a broad range of 2,2'-diiodobiaryls, 2-bromo-2'-iodobiaryls, and 2-chloro-2'-iodobiaryls were obtained under mild reaction conditions. More importantly, a chiral copper-bisoxazoline catalyst system was further developed for the preparation of axially chiral 2,2'-dihalobiaryls in excellent yields and enantioselectivities, which can serve as versatile precursors for the synthesis of various chiral ligands.
MoreTranslated text
Key words
Homogeneous Catalysts
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined