Finding A Proper "Mate": Comparison Of Left Ventricular Assist Devices Using Cerebral Oximetry

Introduction:Axial-flow and centrifugal-flow left ventricular assist devices (LVAD) have been utilized in the management of heart failure, but it remains unknown whether these devices differ in end-organ perfusion. Our goal was to evaluate the association between device type and regional cerebral oxygen saturation (rSO(2)), and determine if this confers any benefit in short-term postoperative outcomes.Methods:Adult patients who underwent primary LVAD implantation at our institution from 2014 to 2019 were retrospectively analyzed. Patients were stratified into axial-flow and centrifugal-flow groups. Intraoperative rSO(2) readings were used to calculate the change in mean rSO(2) from pre- to post-bypass. Multivariable modeling was performed to compare delta rSO(2) between groups, and to analyze the association between LVAD type and postoperative outcomes.Results:There were 152 patients included, of which 76 had an axial-flow device and 76 had a centrifugal-flow device implanted. The rSO(2) level increased from pre-bypass to post-bypass on average 3.5% (CI: 2.1 to 5.0) for the axial group compared to 0.1% (CI: -1.2 to 1.4) for the centrifugal group, which was a significant difference (beta = -2.22, CI: -4.21 to -0.32, p = 0.022). Axial devices approached significance for lower odds of postoperative complications (OR: 0.35, CI: 0.11 to 1.06, p = 0.063), and were associated with significantly shorter ICU LOS (beta = -0.36, CI: -0.60 to -0.11, p = 0.004).Conclusion:Axial devices resulted in a greater increase in rSO(2) than centrifugal pumps after separation from CPB. Further investigation is warranted to evaluate the effect of LVAD selection on long-term end-organ perfusion and subsequent patient outcomes.