Polycystic ovary syndrome: Pro12Ala polymorphism, hormonal and metabolic profiles

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting women and a leading cause of female infertility worldwide. This study aimed to delineate the association between the peroxisome proliferator-activated receptor gamma (PPARG) and the gonadotrophin hormonal disturbance and energy metabolism and its impact on patients with PCOS in Egyptian women. A total of 90 adult women of childbearing age, 40 women were diagnosed by means of ultrasound to be suffering from PCOS, compared to 50 age-matched normal controls. All subjects were examined per PPARG2-Pro12Ala polymorphism, gonadotrophin hormones and metabolic parameters. There was a significant difference with PPARG2-Pro12Ala between Egyptian women with PCOS and controls. Some metabolic parameters were significantly increased in the PCOS patients with Pro12Ala. In conclusion, the PPARG2-Pro12Ala was associated with hormonal disturbed PCOS patients leading to the complications of metabolic syndrome.