Agrimophol suppresses RANKL-mediated osteoclastogenesis through Blimp1-Bcl6 axis and prevents inflammatory bone loss in mice

•AGR inhibited RANKL-induced osteoclast formation.•AGR inhibited F-actin ring formation and osteoclast-mediated bone resorption.•AGR did not affect NF-κB, MAPKs and calcineurin activation and GSK3β inactivation.•AGR inhibited transcription of NFATc1 and its target genes via Blimp1-Bcl6 axis.•AGR mitigated LPS-induced bone loss in mice.