Dynamics of HOX gene expression and regulation in adipocyte development

Vinod Kumar,S Mouliganesh,Priyanka Sarkar,Kshitish K Acharya,Kavitha Thirumurugan

Gene（2021）

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摘要

•Profiling of HOX genes in adipocyte development using transcriptomic data.•Demonstration of time-dependent expression of HOX genes during adipogenesis.•Up-regulation of HOXA5, HOXC13 in pre-adipocyte stage of 3T3-L1 cells.•Up-regulation of HOXD4, HOXD8 in differentiated adipocyte of 3T3-L1 cells.•HOXA5, HOXD4, HOXD8 directly modulated by PPARγ.•Regulation of HOXC13 via Wnt pathway, and PPARγ suppression.

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关键词

HOX,PPARγ,RAR,RXR,GEO,PPRE,DERG,DEG,TF,ChIP-Seq,RSAT,DMEM,IBMX- 3,ATRA,FBS,HDAC,RIPA,SDS,PVDF,HRP,TSA

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