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ZIF-C for targeted RNA interference and CRISPR/Cas9 based gene editing in prostate cancer

Arpita Poddar, Suneela Pyreddy, Francesco Carraro, Sudip Dhakal, Andrea Rassell, Matthew R. Field, T. Srinivasa Reddy, Paolo Falcaro, Cara M. Doherty, Ravi Shukla

CHEMICAL COMMUNICATIONS（2020）

Cited 33|Views40
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Abstract
Gene therapy is highly suited for prostate cancer (PC). Metal-organic-frameworks (MOFs) are potential gene delivery systems. Target-specific cytoplasmic and nuclear knockdown in host gene expression using ZIF-C is shown for the first time through RNAi and CRISPR/Cas9 based gene editing in PC cells. A green tea phytochemical coating enhances intracellular delivery.
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Key words
prostate cancer,crispr/cas9,rna interference
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