Chrome Extension
WeChat Mini Program
Use on ChatGLM
VIPCreated with Sketch.

L, D-Polydeoxyribonucleotides to provide an essential inhibitory effect on DNA polymerase β of human myeloid leukemia HL60 cells

S.V. Stovbun,A.S. Vedenkin,A.A. Bukhvostov,L.S. Koroleva,V.N. Silnikov,D.A. Kuznetsov

Biochemistry and Biophysics Reports（2020）

Cited 4|Views14
No score
Abstract
The inhibitory effect of D and L-polynucleotides of a given length (40-50n) on the catalytic activity of DNA polymerase β isolated from chromatin cells of acute myeloid leukemia HL-60 was evaluated. The synthesized L enantiomer was found to have a higher inhibitory activity than the synthesized and isolated D enantiomers of polynucleotides. The work also proposes a biophysical model that describes this effect.
More
Translated text
Key words
DNA Polymerase β,l-thymidine,HL-60,Leukemia,Polydeoxyribonucleotides,DNA Repair
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined