Chitosan Oligosaccharide-G-Linalool Polymer As Inhibitor Of Hyaluronidase And Collagenase Activity
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES(2021)
Abstract
In this study, chitosan oligosaccharide (COS) was modified by grafting Linalool (Lin) on its backbone to improve its anti-inflammatory activity. By changing the molar ratios of COS to Lin, three different degrees of substitution COS-g-Lin1-3 were prepared. The degrees of substitution of derivatives were 0.65, 0.80 and 1.14 respectively. The structure of COS-g-Lin1-3 were characterized by UV-vis, FT-IR, H-1 NMR and elemental analysis in order to show the COS-g-Lin1-3 successfully synthesized. Besides, the thermal stability, solubility, pH stability as well as crystallinity were also investigated. The results revealed that the derivatives exhibited higher thermal stability and more remarkable anti-inflammatory property against hyaluronidase and collagenase than that of COS. The good biocompatibility made this novel material a promising and effective compound for anti-inflammatory applications. (C) 2020 Elsevier B.V. All rights reserved.
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Key words
Chitosan oligosaccharide, Linalool, Anti-inflammatory activity
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