Design and synthesis of the new scaffolds for anti-tuberculosis compounds using general pharmacophore concept
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY(2016)
摘要
Using general Ser/Thr pharmacophore approach suggested by us previously we have designed two series of compounds capable to suppress the growth of virulent Mycobacterium Tuberculosis strain (H37Rv). We suggest that this inhibition is caused by mycobacterial PknB inhibition.
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关键词
Ser/Thr kinases,Tuberculosis,Pharmacophore,PknB inhibitors
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