3'-Sialyllactose-decorated Silver nanoparticles: lectin binding and bactericidal properties

Simple technique of preparation of sialolectin-specific nanosilver-labeled colloidal neoglycoconjugates, based on maleic anhydride copolymers and beta-N-glycyl-3'-sialyllactose (SL-AgNPs), was developed. Their physicochemical properties were investigated using TEM, UV-vis-, and H-1-NMR spectroscopy. Interaction of SL-AgNPs with sialic acid specific lectin from Maakia amurensis was studied. Minimum inhibitory concentrations of SL-AgNPs for Staphylococcus aureus ATCC 29213 and Enterococcus faecalis ATCC 29212 were also determined. For poly(ethylene-alt-maleic anhydride) based nanocomposite, an additive influence of nanosilver and 3'-sialyllactose on antibacterial activity against Enterococcus faecalis was found.