A new approach for the synthesis of 8-((1,3-diphenyl-4,5-dihydro-1H-pyrazole-5 yl)methoxy)quinoline: a novel lead for breast cancer chemotherapy

The present effort deals with the discovery of highly potent pyrazole bearing quinoline a novel lead for breast cancer chemotherapy. The target molecules were synthesized by 8-hydroxyquinoline and allyl chloride as precursors under basic medium followed by 1,3-dipolar cycloaddition reaction with benzaldehyde phenyl hydrazone under ethanol solvent medium. This reaction route cultivates many advantages such as easy work-up and environment friendly solvent system. At the same time they structurally characterized by H-1-NMR, C-13-NMR, IR spectral data and elemental analysis. In addition to that, the newly obtained compounds were screened for anti-breast cancer activity. Although the cytotoxicity of the obtained analogs was determined using human breast tumor cell lines MCF7, compounds 4b, 4c showed very good effect on MCF7 cancer cells and further, they may helpf to develop a perfect lead for breast cancer MCF7 cell line.