A Small-Sized Benzothiazole-Indolium Fluorescent Probe: The Study Of Interaction Specificity Targeting C-Myc Promoter G-Quadruplex Structures And Live Cell Imaging
CHEMICAL COMMUNICATIONS(2020)
摘要
A small-sized c-MYC promoter G-quadruplex selective fluorescent BZT-Indolium binding ligand was demonstrated for the first time as a highly target-specific and photostable probe for in vitro staining and live cell imaging and it was found to be able to inhibit the amplification of the c-MYC G-rich sequence (G-quadruplex) and down-regulate oncogene c-MYC expression in human cancer cells (HeLa).
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关键词
benzothiazole–indolium fluorescent probe,live cell imaging,small-sized,c-myc,g-quadruplex
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