Systematic approach to selecting licensed drugs for repurposing in the treatment of progressive multiple sclerosis
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY(2021)
摘要
Objective To establish a rigorous, expert-led, evidence-based approach to the evaluation of licensed drugs for repurposing and testing in clinical trials of people with progressive multiple sclerosis (MS). Methods We long-listed licensed drugs with evidence of human safety, blood-brain barrier penetrance and demonstrable efficacy in at least one animal model, or mechanistic target, agreed by a panel of experts and people with MS to be relevant to the pathogenesis of progression. We systematically reviewed the preclinical and clinical literature for each compound, condensed this into a database of summary documents and short-listed drugs by scoring each one of them. Drugs were evaluated for immediate use in a clinical trial, and our selection was scrutinised by a final independent expert review. Results From a short list of 55 treatments, we recommended four treatments for immediate testing in progressive MS: R-alpha-lipoic acid, metformin, the combination treatment of R-alpha-lipoic acid and metformin, and niacin. We also prioritised clemastine, lamotrigine, oxcarbazepine, nimodipine and flunarizine. Conclusions We report a standardised approach for the identification of candidate drugs for repurposing in the treatment of progressive MS.
更多查看译文
关键词
multiple sclerosis,licensed drugs
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要