Long-term inhibition of dipeptidyl-peptidase 4 reduces islet infiltration and downregulates IL-1β and IL-12 in NOD mice
International Immunopharmacology（2020）
Abstract
•DPP-4 inhibition reduced CD4+T cells infiltration and ameliorated insulitis.•DPP-4 inhibition downregulated serum IL-1β and IL-12.•LPS increased CD11b+ cells to infiltrate into islets.
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Key words
DPP-4 inhibitor,Type 1 diabetes,Innate immunity,Islet infiltration,IL-1β,IL-12
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