Emodin improves alveolar hypercoagulation and inhibits pulmonary inflammation in LPS-provoked ARDS in mice via NF-κB inactivation
INTERNATIONAL IMMUNOPHARMACOLOGY(2020)
Abstract
•Intro-alveolar coagulation activation and fibrinolysis inhibition have pivotal role in ARDS pathogenesis. In this manuscript, we pretreated with a traditional Chinese herb for LPS-induced ARDS mice and we interestingly found that emoding significantly inhibited the NF-κB-mediated alveolar hypercoagulation and fibrinolytic inhibition as well as excessive pulmonary inflammation.•Our results demonstrated that emodin protected ARDS mice against LPS-induced lung injury, corrected alveolar hypercoagulation and fibrinolystic inhibition in a dose-dependent manner. And we found the mechanism through which emodin attenuated alveolar hypercoagulation and fibrinolystic inhibition of ARDS mice was to inhibit NF-κB activation.
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Key words
Emodin, Acute respiratory distress syndrome, NF-kappa B pathway, Alvolar hypercoagulation and fibrinolytic inhibition, Pulmonary inflammation
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