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Autophagy inhibition attenuates TGF-β2-induced epithelial–mesenchymal transition in lens epithelial cells

Yan Sun,Lang Xiong,Xiaoran Wang,Liping Wang,Baoxin Chen,Jingqi Huang,Mi Huang,Jieping Chen,Jing Wu,Shan Huang,Yizhi Liu

Life Sciences（2021）

Cited 17|Views22
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Abstract
•Autophagy is activated in TGF-β2-induced EMT in LECs.•Autophagy activation enhances TGF-β2-triggered fibrogenic responses in LECs.•Pharmacological inhibition of autophagy alleviates TGF-β2-induced EMT in LECs.•TGF-β/Smad signaling is involved in the modulation of autophagy on EMT in LECs.•ATG7 knockdown abrogates TGF-β2-induced EMT in LECs.
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Key words
Autophagy,Lens epithelial cells,Epithelial–mesenchymal transition,TGF-β2
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