Synthesis And Biological Evaluation Of New Curcumin Analogs Inhibiting Osteoclastogenesis

A series of curcumin analogs (1-3) were newly designed and synthesized for the development of therapeutic agents for osteoporosis. Among the synthesized compounds, 2,5-substituted conjugated thiophene derivative (la) and the corresponding pyrazine derivative (1e) were shown to be potential leads for the development of anti-osteoclastogenesis agent.