A hydroxyl-functionalized 3D porous gadolinium-organic framework platform for drug delivery, imaging and gas separation

A water-stable 3D porous Gd-based MOF decorated by hydroxyl groups with in topology, {[Gd-2(OH-BDC)(2)(DMF)(2)(H2O)(2)]center dot(H2O)}(n) (1) (OH-H2BDC = 2,5-dihydroxyterephthalic acid, DMF = dimethylformamide) has been prepared and were structurally characterized. The results of TGA and PXRD revealed that 1 shows high thermal stability up to 350 degrees C and good water stability. 1 exhibits a 3D framework with 1D channel of 8.4 x 8.1 angstrom(2) parallel to the c axis. Activated 1 (la) shows an 5-Fluorouracil payload of 23.2 wt% and higher signal enhancement ability than Gd-DTPA with the r(1) value being 31.20 mM(-1) S-1. Meanwhile, la exhibits selective CO2 uptake compare with CH4, N-2, O-2, and H-2 at room temperature under simulation condition. Furthermore, the magnetic property, in vitro MTT assays and in vivo Zebrafish toxicity tests of 1 have also been carried out.