Does Mycobacterium bovis persist in cattle in a non-replicative latent state as Mycobacterium tuberculosis in human beings?

•M. tuberculosis mostly causes latent infection in mammals, whereas M. bovis mostly produces an acute infection.•The in vitro macrophage cellular responses to M. bovis and M. tuberculosis differ significantly.•Stress transcriptional programs respond differently between M. bovis and M. tuberculosis.