A safe non-toxic Brucella abortus ghosts induce immune responses and confer protection in BALB/c mice.

Shuli Wang,Zhiqiang Li,Jinliang Zhang,Li Xi,Yanyan Cui, Wehihua Zhang,Junbo Zhang,Hui Zhang

Molecular Immunology（2020）

引用 6|浏览10

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摘要

•The 2308ΔgntR ghost is non-toxic in mice.•The 2308ΔgntR ghost can elicit an anti-Brucella-specific IgG response.•2308ΔgntR ghost immunizations induce a cellular response.•2308ΔgntR ghost induces protection against B. abortus challenge.•2308ΔgntR ghost can enhance splenic T lymphocyte activity.

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关键词

B. abortus 2308,Brucella ghosts,GntR,Protective efficacy

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