Design and Synthesis of 3,6-Disubstituted- and 2,3,6-Trisubstitutedquinoxalines: Docking and In Vitro Antimicrobial Study

Antimicrobial chemotherapy is the clinical application of antimicrobial agents to treat infectious disease. A new series of 3,6-disubstituted- and 2,3,6-trisubstitutedquinoxalines have been synthesized by appropriate methods. All test compounds have been evaluated for in vitro antimicrobial activity. Further investigation using MIC experiment was performed; It appears that, compound 14c has higher broad-spectrum antibacterial activity (MIC= 0.01–0.24 ug/ml) than the reference drug, streptomycin (MIC= 0.03–0.97 ug/ml). As well, it elicited remarkable antifungal activity than the reference drug clotrimazole against almost all the selected strains. Moreover, docking study of the most active compounds into MurF active site has confirmed their binding affinity to MurF.