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685 Targeted degradation of CD147 proteins in melanoma

Z. Zhou,J. Long,X. Chen,C. Peng

Journal of Investigative Dermatology（2020）

Cited 9|Views46
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Abstract
Proteolysis targeting chimeras (PROTACs) are chimeric small molecules with a linker that enable simultaneous binding to a target protein and an E3 ligase, thereby leading to ubiquitination and subsequent degradation of the target. Ubiquitin can be recycled.
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Key words
CD147,PROTAC,Degradation,Pseudolaric Acid B,Melanoma
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