26. Community engagement for crowd-sourcing clinically relevant somatic variants, the CIViC experience.

The crowd-sourced, public domain knowledgebase CIViC (Clinical Interpretations of Variants in Cancer; civicdb.org) is composed of literature-derived evidence for the clinical utility of cancer variants. Evidence is captured in CIViC using concepts from established ontologies and CIViC-defined descriptive fields alongside human-readable text. This structured data allows for complex searches, programmatic access, and rapid integration into other resources. Anyone can curate evidence for CIViC by creating a login. CIViC content is freely available without registration via the web interface, text downloads or API access, and has been attributed to the public domain (CC0) declaration. While content in any stage is always available, high-quality content is supported by a gate-keeper model with labels clearly denoting expert-moderated content.