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Ginsenoside Rg1 protects against aging-induced renal interstitial fibrosis due to inhibition of tubular epithelial cells endoplasmic reticulum stress in SAMP8 mice

Shixin Ding,Han Zhang,Zhenghao Sun,Yuli Han,Yan Li,Xianan Dong,Yanyan Yin,Weiping Li,Weizu Li

Journal of Functional Foods（2020）

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Abstract
•ER stress involves in aging-related interstitial fibrosis in kidney aging in mice.•Rg1 treatment significantly decreased renal interstitial fibrosis in SAMP8 mice.•Rg1 treatment significantly inhibited ER stress in renal tissues in SAMP8 mice.•Rg1 may be a potential agent for delaying the progression of kidney aging.
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ginsenoside Rg1,Endoplasmic reticulum stress,Renal tubular epithelial cells,Apoptosis,Renal interstitial fibrosis
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